Wydział Chemii

Tomasz Janeczko

Jadwiga Dmochowska-Gładysz

Edyta Kostrzewa-Susłow

Agata Białońska

Zbigniew Ciunik

2009

Steroids

74

657-661

10.1016/j.steroids.2009.02.006

Naukowa

Angielski

Artykuł

Biotransformations of steroid compounds: androstenedione, testosterone, progesterone, pregnenolone and DHEA using Chaetomium sp. 1 KCH 6651 strain as a biocatalyst were investigated. The microorganism proved capable of selective hydroxylation of the steroid substrates. Androstenedione was converted to 14alpha-hydroxyandrost-4-en-3,17-dione (in over 75% yield) and 6beta-hydroxyandrost-4-en-3,17-dione (in low yield), while testosterone underwent regioselective hydroxylation at 6beta position. Progesterone was transformed to a single product-6beta,14alpha-dihydroxypregnan-4-en-3,20-dione in high yield, whereas biotransformation of DHEA resulted in the formation of 7alpha-hydroxy derivative, which was subsequently converted to 7alpha-hydroxyandrost-4-en-3,17-dione.

Biotransformation, Hydroxylation, androstendione, Progesterone, DHEA, Chaetomium sp

https://doi.org./ 10.1016/j.steroids.2009.02.006

http://www.elsevier.com