Wydział Chemii

Joanna Masternak

Barbara Barszcz

Wanda Sawka-Dobrowolska

Joanna Wietrzyk

Julia Jezierska

Magdalena Milczarek

2014

RSC Advances

4

43962-43972

10.1039/C4RA07960D

Naukowa

Angielski

Artykuł

We have demonstrated a simple process that involves one-pot, one-step reactions leading to efficient preparation of new cadmium complexes with N4-donating ligands [CdX₂L¹] (X = I⁻ (1), Br⁻ (2) L¹ = tris(1-(3,5-dimethylpyrazolyl)methyl)amine). The most prominent feature of the synthesis is the in situ formation of a new organic tripodal ligand (L¹) in a condensation reaction between a starting ligand (1-hydroxymethyl-3,5-dimethylpyrazole) and ammonia. A single-crystal X-ray analysis confirmed that the complexes obtained are monomers (1, 2) with octahedral geometry of the cadmium centres. Complex 3 has a cationic–anionic structure [Cu(LOH)₂CH₃OH][CdCl₄] and has been synthesised by the reaction of CdO and NH₄Cl in the presence of zerovalent copper (powder). IR, EPR, ¹H and ¹³C NMR, as well as simultaneous TG/DTG were carried out to characterise the products. Moreover, we try to compare the cytotoxic profile of CdO and cadmium salts with Cd(II) complexes. Besides [CdX₂L¹] (1, 2) we take into consideration [Cd₂(L²)₂(SCN)₄(MeOH)₂]_n (4) and [Cd(SCN)₂L¹] (5) complexes. Biological studies demonstrated that Cd(II) complexes with the N-scorpionate ligand (1, 2 and 5) have similar cytotoxicity, which points to a structure–cytotoxicity relationship. Thus, all the complexes (except 4) exhibited a lower cytotoxic activity compared to a cadmium ion in salts.

http://dx.doi.org/10.1039/C4RA07960D

https://www.rsc.org/