Repozytorium
Wyszukaj
Kolekcje
Inne
Application of 1,2,4-triazolo[1,5-α]pyrimidines for the design of coordination compounds with interesting structures and new biological properties.
Autorzy
Rok wydania
2016
Czasopismo
Coordination Chemistry Reviews
Numer woluminu
327-328
Strony
221-241
DOI
10.1016/j.ccr.2016.04.014
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
This article reviews investigations conducted over the last 15 years that aimed to develop coordination compounds with 1,2,4-triazolo[1,5-a]pyrimidines. The rich diversity of this coordination chemistry provides not only interesting structural chemistry but also exciting therapeutic properties. In particular, these compounds have gained increasing attention in medicinal applications, such as anticancer, antiparasitic and antibacterial prodrugs, and most of these coordination compounds are hypothesized to exhibit higher therapeutic potential than the currently available drugs. In addition, possible structure–activity relationships are discussed and outlined.
Słowa kluczowe
Triazolopyrimidine, Metal complexes, Biological activity
Adres publiczny
http://dx.doi.org/10.1016/j.ccr.2016.04.014
Strona internetowa wydawcy
Podobne publikacje
Copper(II) complexes of alloferon 1 with point mutations (H1A) and (H9A) stability structure and biological activity.
Matusiak Agnieszka, Kuczer Mariola, Czarniewska Elżbieta, Rosiński Grzegorz, Kowalik-Jankowska Teresa
Crystal and molecular structure of 1,4-S,S'-bis-isothiosemicarbazidebutane dihydrobromide.
Ciunik Zbigniew, Drabent Krzysztof, Rudolf Mikołaj F.
Copper(II) complexes of terminally free alloferon peptide mutants containing two different histidyl (H1 and H6 or H9 or H12) binding sites structure stability and biological activity.
Matusiak Agnieszka, Kuczer Mariola, Czarniewska Elżbieta, Urbański Arkadiusz, Rosiński Grzegorz, Kowalik-Jankowska Teresa