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Antiviral, antibacterial, antifungal, and cytotoxic silver(I) bioMOF assembled from 1,3,5-triaza-7-phoshaadamantane and pyromellitic acid.

Autorzy

Sabina W. Jaros

Jarosław Król

Barbara Bażanów

Dominik Poradowski

Aleksander Chrószcz

Dmytro S. Nesterov

Alexander M. Kirillov

Piotr Smoleński

Rok wydania

2020

Czasopismo

Molecules

Numer woluminu

25

Strony

2119/1-2119/13

DOI

10.3390/molecules25092119

Kolekcja

Naukowa

Język

Angielski

Typ publikacji

Artykuł

Streszczenie

The present study reports the synthesis, characterization, and crystal structure of a novel bioactive metal-organic framework, [Ag4(µ-PTA)2(µ3-PTA)2(µ4-pma)(H2O)2]n·6nH2O (bioMOF 1), which was assembled from silver(I) oxide, 1,3,5-triaza-7-phosphaadamantane (PTA), and pyromellitic acid (H4pma). This product was isolated as a stable microcrystalline solid and characterized by standard methods, including elemental analysis, 1H and 31P{1H} NMR and FTIR spectroscopy, and single crystal X-ray diffraction. The crystal structure of 1 disclosed a very complex ribbon-pillared 3D metal-organic framework driven by three different types of bridging ligands (µ-PTA, µ3-PTA, and µ4-pma4-). Various bioactivity characteristics of bioMOF 1 were investigated, revealing that this compound acts as a potent antimicrobial against pathogenic strains of standard Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria, as well as a yeast (Candida albicans). Further, 1 showed significant antiviral activity against human adenovirus 36 (HAdV-36). Finally, bioMOF 1 revealed high cytotoxicity toward an abnormal epithelioid cervix carcinoma (HeLa) cell line with low toxicity toward a normal human dermal fibroblast (NHDF) cell line. This study not only broadens the family of PTA-based coordination polymers but also highlights their promising multifaceted bioactivity.

Słowa kluczowe

metal-organic frameworks, coordination polymers, silver complexes, atom, Ion, 5-triaza-7-phosphaadamantane, pyromellitic acid, antimicrobial activity, cytotoxic activity, antiviral activity

Licencja otwartego dostępu

CC-BY

Licencja na prawach której można swobodnie kopiować, rozprowadzać, zmieniać i remiksować objęty prawem autorskim utwór (Utwór-przedmiot prawa autorskiego) pod warunkiem podania imienia i nazwiska autora utworu pierwotnego oraz źródła pochodzenia utworu.

Pełny tekst licencji: https://creativecommons.org/licenses/by/3.0/pl/legalcode

Adres publiczny

http://dx.doi.org/10.3390/molecules25092119

Strona internetowa wydawcy

http://www.mdpi.com/journal/metals

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