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Inne
Bioactive silver—organic networks assembled from 1,3,5-triaza-7-phosphaadamantane and flexible cyclohexanecarboxylate blocks.
Autorzy
Rok wydania
2016
Czasopismo
Numer woluminu
55
Strony
1486-1496
DOI
10.1021/acs.inorgchem.5b02235
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Three novel bioactive silver–organic networks, namely, the 2D polymer [Ag(μ3-PTA)(chc)]n·n(Hchc)·2nH2O (1), the 3D bioMOF [Ag2(μ3-PTA)2(μ2-chdc)]n·5nH2O (2), and the 2D polymer [Ag2(μ2-PTA)2(μ4-H2chtc)]n·6nH2O (3), were constructed from 1,3,5-triaza-7-phosphaadamantane (PTA) and various flexible cyclohexanecarboxylic acids as building blocks {cyclohexanecarboxylic (Hchc), 1,4-cyclohexanedicarboxylic (H2chdc), and 1,2,4,5-cyclohexanetetracarboxylic (H4chtc) acid, respectively}. The obtained products 1–3 were fully characterized by IR and NMR spectroscopy, ESI-MS(±) spectrometry, elemental and thermogravimetric (TGA) analyses, and single-crystal and powder X-ray diffraction. Their structural diversity originates from distinct coordination modes of cyclohexanecarboxylate moieties as well as from the presence of unconventional N,N,P-tridentate or N,P-bidentate PTA spacers. Topological classification of underlying metal–organic networks was performed, disclosing the hcb, 4,4L28, and a rare fsc-3,4-Pbcn-3 topology in 1, 2, and 3, respectively. Moreover, combination of aqueous solubility (S25°C ≈ 4–6 mg mL–1), air stability, and appropriate coordination environments around silver centers favors a release of bioactive Ag+ ions by 1–3, which thus act as potent antibacterial and antifungal agents against Gram-positive (S. aureus) and Gram-negative (E. coli and P. aeruginosa) bacteria as well as a yeast (C. albicans). The best normalized minimum inhibitory concentrations (normalized MIC) of 10–18 (for bacterial strains) or 57 nmol mL–1 (for a yeast strain) were achieved. Detailed ESI-MS studies were performed, confirming the relative stability of 1–3 in solution and giving additional insight on the self-assembly formation of polycarboxylate Ag–PTA derivatives and their crystal growth process.
Adres publiczny
http://dx.doi.org/10.1021/acs.inorgchem.5b02235
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