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The immunosuppressive activity and solution structures of ubiquitin fragments.
Autorzy
Rok wydania
2009
Czasopismo
Numer woluminu
91
Strony
423-431
DOI
10.1002/bip.21160
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Recently, ubiquitin was suggested as a promising anti-inflammatory protein therapeutic. We found that a peptide fragment corresponding to the ubiquitin(50-59) sequence (LEDGRTLSDY) possessed the immunosuppressive activity comparable with that of ubiquitin. CD and NMR spectroscopies were used to determine the conformational preferences of LEDGRTLSDY in solution. The peptide mixture, obtained by pepsin digestion of ubiquitin, was even more potent than the intact protein. Although the peptide exhibited a well-defined conformation in methanol, its structure was distinct from the corresponding 50-59 fragment in the native ubiquitin molecule.
Słowa kluczowe
ubiquitin, immunomodulation, retro‐RGD sequence, solution structure, NMR, peptic fragments, cryptides
Adres publiczny
https://doi.org/10.1002/bip.21160
Strona internetowa wydawcy
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