Repozytorium
Wyszukaj
Kolekcje
Inne
Sulfonated analogues of cyclolinopeptide A. Synthesis, immunosuppressive activity and CD studies.
Autorzy
Rok wydania
1997
Czasopismo
Numer woluminu
49
Strony
415-420
DOI
10.1111/j.1399-3011.1997.tb00893.x
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Linear and cyclic analogues of cyclolinopeptide A (CLA) in which one or both phenylalanine residues in fragment Pro6-Pro7-Phe8-Phe9 were substituted by their sulfonated derivatives have been synthesized by SPPS method and cyclization with the BOP reagent. The peptides were examined for their immunosuppressive activity in the humoral and cellular immune response by PFC and DTH tests. All of the analogues retain some immunosuppressive activity of native CLA. Their CD spectra confirm that the optical activity of aromatic residues in CLA depends on their position in the peptide chain. Only the residue in position 8 seems to be optically active. CD spectrum of the cyclic analogue modified in position 9 is very similar to that of native CLA which correlates with its high biological activity. The chiroptical properties of the p-sulfonated Phe-residue are established.
Adres publiczny
https://doi.org/ 10.1111/j.1399-3011.1997.tb00893.x
Strona internetowa wydawcy
Podobne publikacje
New analogues of cyclolinopeptide A : immunosuppressive activity and CD studies.
Cebrat Marek, Lisowski Marek, Siemion Ignacy Z., Wieczorek Zbigniew
Immunosuppressive activity of tyrosine analogues of cyclolinopeptide A.
Wieczorek Zbigniew, Pędyczak Artur, Bodalski T., Lisowski Marek, Trojnar J., Zimecki Michał, Siemion Ignacy Z.
Immunosuppressive activity of threonine-containing analogues of cyclolinopeptide A.
Siemion Ignacy Z., Cebrat Marek, Lisowski Marek, Zimecki Michał, Wieczorek Zbigniew