Repozytorium
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Inne
Synthesis of linear and cyclic opioid-based peptide analogs containing multiple N-methylated amino acid residues.
Autorzy
Rok wydania
2015
Czasopismo
Numer woluminu
21
Strony
807-810
DOI
10.1002/psc.2804
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A series of six novel opioid peptide analogs containing one to three N-methylamino acid residues, and six cyclic counterparts of these peptides were prepared by the solid-phase method. Introduction of two consecutive N-methylated amino acids, as well as cyclization of such conformationally constrained sequences, turned out to be challenging. The use of a recently reported triazine-based coupling reagent, 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium toluene-4-sulfonate, enabled the synthesis and cyclization of the designed analogs in acceptable yields and with a lesser amount of by-products than observed with the standard coupling reagents such as TBTU or HATU.
Słowa kluczowe
peptide synthesis, cyclization, coupling reagents, N-methylated amino acids
Adres publiczny
http://dx.doi.org/10.1002/psc.2804
Strona internetowa wydawcy
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