Wydział Chemii

Riccardo Pettinari

Fabio Marchetti

Agnese Petrini

Claudio P. Pettinari

Giulio Lupidi

Piotr Smoleński

Rosario Scopelliti

Tina Riedel

Paul J. Dyson

2016

Organometallics

35

3734-3742

10.1021/acs.organomet.6b00694

Naukowa

Angielski

Artykuł

A series of ruthenium(II) arene derivatives (arene = cymene (cym), hexamethylbenzene (hmb)) containing avobenzone (1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, AVBH) and PTA (1,3,5-triaza-7-phosphaadamantane) or PTA-Me (N-methyl-1,3,5-triaza-7-phosphaadamantane cation) have been synthesized and fully characterized. Three types of complexes have been obtained: i.e., neutral [Ru(arene)(AVB)Cl] (1, arene = cym; 2, arene = hmb), monocationic [Ru(arene)(AVB)(PTA)][SO₃CF₃] (3, arene = cym; 4, arene = hmb), and dicationic [Ru(arene)(AVB)(PTA-Me)][SO₃CF₃][BF₄] (5, arene = cym; 6, arene = hmb). The solid-state structures of 1 and 2 were determined by single-crystal X-ray diffraction. The cytotoxicity of the complexes has been evaluated in vitro against human ovarian carcinoma cells, A2780 and A2780cisR, as well as against nontumorous Human Embryonic Kidney (HEK293) cells. The ionic complexes with hydrophilic PTA and PTA-Me ligands in 3–6 are considerably more active than the neutral complexes 1 and 2.

http:/dx.doi.org/10.1021/acs.organomet.6b00694

https://www.acs.org/content/acs/en.html