Repozytorium
Wyszukaj
Kolekcje
Inne
Two-fold modification of the phenyl substituent in phenylphosphonic acid monoester monoamides.
Autorzy
Rok wydania
2012
Czasopismo
Numer woluminu
77
Strony
8244-8256
DOI
10.1021/jo301526k
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Phenylphosphonic acid ethyl ester N,N-diethylamide was subjected to a double modification of its phenyl substituent through directed ortho-metalation followed by dearomatization of the aryl substituent under Birch reduction conditions. Application of the same methodology to a diastereomerically pure phenylphosphonic acid monoester monoamide led to the formation of P-stereogenic cyclohexadienyl-phosphonic acid derivatives. The method offers a simple and efficient modification of phenyl substituent in organophosphorus compounds.
Adres publiczny
http://dx.doi.org/10.1021/jo301526k