Wydział Chemii

Ali Akbari

Nasrollah Jabbari

Roholah Sharifi

Mahdi Ahmadi

Ali Vahhabi

Seyyed Javad Seyedzadeh

Muhammad Nawaz

Sławomir Szafert

Monireh Mahmoodi

Esmaiel Jabbari

Rahim Asghari

Jafar Rezaie

2020

Life Sciences

249

117447/1-117447/12

10.1016/j.lfs.2020.117447

Naukowa

Angielski

Artykuł

Over the last few decades, mesenchymal stem cells-derived exosomes (MSCs-Ex) have attracted a lot of attention as a therapeutic tool in regenerative medicine. Exosomes are extracellular vehicles (EVs) that play important roles in cell-cell communication through various processes such as stress response, senescence, angiogenesis, and cell differentiation. Success in the field of regenerative medicine sparked exploration of the potential use of exosomes as key therapeutic effectors of MSCs to promote tissue regeneration. Various approaches including direct injection, intravenous injection, intraperitoneal injection, oral administration, and hydrogel-based encapsulation have been exploited to deliver exosomes to target tissues in different disease models. Despite significant advances in exosome therapy, it is unclear which approach is more effective for administering exosomes. Herein, we critically review the emerging progress in the applications of exosomes in the form of free or association with hydrogels as therapeutic agents for applications in regenerative medicine.

Exosome, Hydrogels, Mesenchymal stem cell, Regenerative medicine

http://dx.doi.org/10.1016/j.lfs.2020.117447

http://www.elsevier.com