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Interactions of Cu2+ ions with chicken prion tandem repeats.
Autorzy
Rok wydania
2004
Czasopismo
Strony
2102-2107
DOI
10.1039/B405753H
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The potentiometric and spectroscopic (EPR, UV-Vis, CD) data have shown that the chicken prion hexa-repeat (Ac–His–Asn–Pro–Gly–Tyr–Pro–NH2) is a very specific ligand for Cu2+ ions. The His imidazole is an anchoring binding site, then the adjacent amide nitrogen coordinates as a second donor. The presence of Pro at position 3 induces binding of phenolate oxygen as a third donor atom. The tridentate coordination dominates around physiological pH. Similar to human octapeptide fragments, chicken tandem repeats exhibit a cooperative effect in binding Cu2+ ions, although chicken peptides are much less effective in metal ion coordination.
Adres publiczny
https://doi.org/10.1039/B405753H
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