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Cyclolinopeptides and their analogs - a new family of peptide immunosuppressants affecting the calcineurin system.
Autorzy
Rok wydania
1999
Czasopismo
Archivum Immunologiae et Therapiae Experimentalis
Numer woluminu
47
Strony
143-153
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The results of the investigation of immunosuppressive activity of cyclolinopeptide A (CLA--cyclic hydrophobic nonapeptide present in the linseeds) and its analogs are discussed. The results obtained for other natural cyclic peptides showing structural similarities with CLA (antamanide, cycloamanides, hymenistatin, hymenamides) are also reviewed. It results from these investigations that the molecular mechanism of the CLA action is the same as that of cyclosporin A and FK-506 compound, i.e. it consists in formation of the complex with cyclophilin and inhibition--in this form--of the phosphatase activity of calcineurin. The results also suggest that the immunosuppressive activity of these compounds resides in their--Pro-Xxx-Phe- fragment, where Xxx is a hydrophobic (e.g. Leu, Val) or aromatic amino acid residue.