Repozytorium
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Kolekcje
Inne
The effects of morphology and linker length on the properties of peptide–lanthanide upconversion nanomaterials as G2 phase cell cycle inhibitors.
Autorzy
Rok wydania
2015
Czasopismo
European Journal of Inorganic Chemistry
Strony
4539-4545
DOI
10.1002/ejic.201500321
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
In this work, the shape effect of our same-sized hybrid nanomaterials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF4@SiO2-P1 nanoparticles achieve the best performance for in vitro imaging, G2 phase cell arrest, and, hence, cell cycle inhibition.
Słowa kluczowe
nanoparticles, Peptides, lanthanides, medicinal chemistry, imaging agents, anitumor agents, inhibitors
Adres publiczny
http://dx.doi.org/10.1002/ejic.201500321
Strona internetowa wydawcy
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