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Inne
A study of the comparative donor properties to CuII of the terminal amino and imidazole nitrogens in peptides.
Autorzy
Rok wydania
1990
Czasopismo
Journal of the Chemical Society, Dalton Transactions
Strony
3565-3570
DOI
10.1039/DT9900003565
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The synthesis of the tetrapeptides Ala-Gly-Gly-His, Boc-Ala-Gly-Gly-His (Boc = t-butoxycarbonyl), Ala-Gly-Gly-His(π-bom)(π-bom =Nπ-benzoxymethyl), Ala-Gly-Gly-His-OMe, and Ala-Gly-Pro-His is reported, together with the results of a pH-metric and spectroscopic (absorption, c.d., and e.s.r.) study of their complexes with H+ and CuII. The work was designed to study the initial site of binding to CuII in peptides containing both a terminal amino nitrogen and a histidyl residue. Results show that the π-N of the imidazole ring of the histidyl residue is the primary anchoring site for copper(II) co-ordination, and that the next nitrogen to bond can be the terminal amino N, forming a macrocyclic chelate ring.
Adres publiczny
https://doi.org/10.1039/DT9900003565
Strona internetowa wydawcy
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