Repozytorium
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Kolekcje
Inne
Immunosuppressive activity of antamanide and some of its analogues.
Autorzy
Rok wydania
1992
Czasopismo
Numer woluminu
13
Strony
1233-1237
DOI
10.1016/0196-9781(92)90034-Z
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
In connection with our discovery of a strong immunosuppressive activity of cyclolinopeptide A (CLA), we investigated immunosuppressive properties of antamanide and a number of its analogues, including symmetrical antamanide, and compared them with the activities of cyclosporin A and CLA. The peptides were investigated by using plaque forming cell (PFC), graft-versus-host (GvH), delayed type hypersensitivity (DTH), and autologous rosette formation cell (ARFC) tests. Antamanide and symmetrical antamanide exhibit an immunosuppressive activity lower than CLA. Linear antamanide fragments are also active. At higher concentrations of the latter peptides, toxic effects occur.
Słowa kluczowe
Antamanide, Symmetrical antamanide, Cyclolinopeptide A, Immunosuppressive activity
Adres publiczny
https://doi.org/10.1016/0196-9781(92)90034-Z
Strona internetowa wydawcy
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