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Inne
Copper(II)-lincomycin: complexation pattern and oxidative activity.
Autorzy
Rok wydania
2001
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
84
Strony
189-200
DOI
10.1016/s0162-0134(01)00167-2
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Coordination of Cu(II) to lincomycin was studied by potentiometry, UV-Vis, circular dichroism (CD), EPR, NMR, cyclic voltammetry (CV) and ESI-MS. Only mononuclear complexes of stoichiometries ranging from CuL to CuH(-3)L were found. In the main species present at neutral pH, CuH(-2)L, lincomycin bonds Cu(II) through both of its nitrogen donors, and a deprotonated oxygen donor at C4 of the sugar moiety. High pressure liquid chromatography (HPLC) of products of 2'-deoxyguanosine (dG) oxidation and agarose gel electrophoresis of plasmid DNA confirmed that lincomycin complexes effectively facilitate dG oxidation by H2O2, but are not able to cleave double-stranded plasmid DNA.
Adres publiczny
http://dx.doi.org/10.1016/s0162-0134(01)00167-2
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