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Impact of α,β-dehydroamino acid residues on the binding abilities of di-, tri- and tetra-peptides.

Autorzy

Jolanta Świątek-Kozłowska

Justyna Brasuń

Longin Chruściński

E. Chruścińska

Maciej Makowski

Henryk Kozłowski

Rok wydania

2000

Czasopismo

New Journal of Chemistry

Numer woluminu

24

Strony

893-896

DOI

10.1039/B004790M

Kolekcja

Naukowa

Język

Angielski

Typ publikacji

Artykuł

Streszczenie

Insertion of a dehydroamino acid residue into a sequence of di-, tri- or tetra-peptide changed considerably the binding abilities of peptide ligands towards copper(II) ions. Potentiometric and spectroscopic (EPR, UV-VIS and CD) data have shown that the amide nitrogen of the dehydroamino acid residue is more effective in co-ordination than its parent analogue. In the case of the bulky ΔPhe residue also the (Z–E) isomerisation has a critical impact on the co-ordination equilibria in the system studied.

Adres publiczny

https://doi.org/10.1039/B004790M

Strona internetowa wydawcy

https://www.rsc.org/

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