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Nucleotide-amino acid interactions in the L-His-IMP·MeOH·H2O complex.
Autorzy
Rok wydania
2010
Czasopismo
Acta Crystallographica Section C: Structural Chemistry
Numer woluminu
C66
Strony
o265-o269
DOI
10.1107/S0108270110014381
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
In the crystal structure of the methanol-solvated monohydrated complex of L -histidine (His) with inosine 5′-monophosphate (IMP), namely L -histidinium inosine-5′-phosphate methanol solvate monohydrate, C6H10N3O2+·C10H12N4O8P−·CH3OH·H2O, most of the interactions between IMP anions (anti/C3′-endo/gauche–gauche conformers) are realized between the riboses and hypoxanthine bases in a trans sugar-edge/sugar-edge geometry, and between the phosphate groups. The base Watson–Crick edge is involved in additional methanol-mediated IMP⋯MeOH⋯IMP contacts. Specific and nonspecific nucleotide–amino acid (IMP⋯His) interactions engage the Hoogsteen edges of the base and phosphate group, respectively. Additional stabilization of His⋯IMP contacts is provided by π–π stacking between the imidazolium ring of His and the hypoxanthine base of IMP. The results may indicate the possible recognition mechanism between His and IMP.
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