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Lighting up peptides: direct dehydroalanine formation from diselenides via Rose Bengal photocatalysis
Autorzy
Rok wydania
2025
Czasopismo
Numer woluminu
61
Strony
11975-11978
DOI
10.1039/d5cc03361f
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A visible-light-driven method for the site-selective conversion of diselenide-containing peptides to dehydroalanine (Dha) is presented. Using Rose Bengal as a photosensitizer in aqueous conditions, this photocatalytic process proceeds via oxidative cleavage of the Se–Se bond followed by β-elimination to afford Dha with high yield and chemoselectivity. This mild and bioorthogonal strategy enables downstream peptide functionalization and offers a practical route for post-synthetic peptide editing.
Adres publiczny
http://dx.doi.org/10.1039/d5cc03361f