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From structural properties of the EuIII complex with ethylenediaminetetra(methylenephosphonic acid)(H8EDTMP) towards biomedical applications.
Autorzy
Rok wydania
2006
Czasopismo
Strony
4702-4710
DOI
10.1039/B606420E
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Crystals of EuIII with ethylenediaminetetra(methylenephosphonic acid) (H8EDTMP) and with ethylenediaminetetraacetic acid (H4EDTA) have been synthesized in the same experimental conditions and their X-ray analyses have been performed. The EDTMP ligand wraps the EuIII ion in a fashion similar to its carboxylic analogue, EDTA, i.e. coordinating through two nitrogen atoms and four oxygen atoms in such a way that only one oxygen atom from each phosphonate group is bonded to the central ion. The coordination sphere is completed by two oxygen atoms of the bidentate carbonate anion in the case of the EuIII–EDTMP complex, whereas the inner sphere of the EuIII–EDTA crystal is completed by three water molecules. Spectroscopic studies (UV-Vis and 31P NMR spectra) of EuIII–EDTMP solutions at controlled pH showed that the replacement of inner sphere water molecules and/or OH hydroxy groups by a carbonate anion in the EuIII–EDTMP complex at physiological pH results in the formation of [Eu(EDTMP)(CO3)]7− species which is thermodynamically stable and kinetically inert. The affinity of the carbonate anion towards the EuIII–EDTMP species was studied by analysis of f–f intensities and luminescence decay rates. The dissociation constant of the EuIII–EDTMP–carbonate complex was found to be approximately 43 mM. The presented results may be helpful in understanding the role played by the 153SmIII–EDTMP complex known as Quadramet® in the seeking of metastatic tissue in bones as well as possibly giving some premises for future ligand design of these types of complexes with lanthanide radionuclides.
Adres publiczny
DOI https://doi.org/10.1039/B606420E
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