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Inne
Effect of the tetrazole cis-amide bond surrogate on the complexing ability of some enkephalin analogues toward Cu(II) ions.
Autorzy
Rok wydania
1999
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
76
Strony
1-11
DOI
10.1016/S0162-0134(99)00098-7
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A study of the effect of the tetrazole moiety, a cis-amide bond surrogate, on the Cu(II) coordinating properties of oligopeptides is reported. The insertion of the tetrazole moiety ψ(CN4) into the peptide sequence of [Leu5]enkephalin considerably changes the coordination ability of the ligand. Potentiometric and spectroscopic results indicate that if the tetrazole moiety is in a suitable position in the peptide chain, i.e. if it follows the third residue, an unusual stable CuH−1L species involving 4N coordination is formed in the physiological pH region. The tetrazole ψ(CN4) ring provides one of these nitrogens. The data indicate that Cu(II) ions are strongly trapped inside a bent peptide backbone. However, the coordination mode involving the tetrazole ring nitrogen does not prevent the hydrolysis process under strongly basic conditions.
Adres publiczny
https://doi.org/10.1016/S0162-0134(99)00098-7