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Inne
Nickel binding sites : coordination modes and thermodynamics.
Autorzy
Rok wydania
2017
Wydawca
Royal Society of Chemistry
Miejsce wydania
Cambridge
Strony
43-59
DOI
10.1039/9781788010580-00043
Tytuł książki
The biological chemistry of nickel.
ISBN
978-1-78262-498-1
Kolekcja
Język
Angielski
Typ publikacji
Rozdział książki
Nickel, the main character of this book, is a key player of several enzymes, present mostly in lower organisms. The metal is completely unnecessary for humans and crucial for the survival and virulence of pathogens, therefore its coordination chemistry could be an excellent therapeutic target. In this chapter, we explain the coordination chemistry of nickel, focusing on its protein binding properties. Detailed descriptions of complex binding modes are intertwined with explorations of chemically fascinating binding sites in bacterial proteins, such as the cysteine-rich or poly-histidine repeats in nickel chaperones of Helicobacter pylori.
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