Wydział Chemii

Radosław Starosta

Kamila Stokowa

Magdalena Florek

Jarosław Król

A. Chwiłkowska

Julita Kulbacka

J. Saczko

Jacek Skała

Małgorzata Jeżowska-Bojczuk

2011

Journal of Inorganic Biochemistry

105

1102-1108

10.1016/j.jinorgbio.2011.05.007

Naukowa

Angielski

Artykuł

This paper presents the biological activity of copper(I) iodide complexes with 1,10-phenanthroline (phen) or 2,9-dimethyl-1,10-phenanthroline (dmp) and three tris (aminomethyl) phosphanes: P(CH2N(CH2CH2)2NCH3)3 (1), P(CH2N(CH2CH2)2O)3 (2) and P (CH2N(CH3)CH2CH2OH)3 (3). Crystallographic and DFT data indicate a significantly stronger binding ability of 3 in the complexes [CuI (phen) P (CH2N (CH3)CH2CH2OH)3] (3P) and [CuI(dmp)P(CH2N(CH3)CH2CH2OH)3] (3N) in comparison to the 1 or 2 ligands. Most probably, this is caused by the relatively small steric requirements of 3. The complexes with dmp exhibit a very high in vitro activity against the Staphylococcus aureus strain (MIC - minimal inhibitory concentration: 2.5-5 μg/mL) and Candida albicans diploid fungus (MIC: 1.25-2.5 μg/mL). All the tested complexes also show a strong in vitro antitumor activity against human ovarian carcinoma cell lines: MDAH 2774 (IC50: 7-2 μM) and cisplatin-resistant SCOV3 (IC50: 3-2 μM). Interestingly, the complexes with dmp of higher biological activity more weakly interact with bovine serum albumin (BSA) and less efficiently cleave the pBluescriptSK+ plasmid.

Copper(I) complexes, Aminomethylphosphanes, Antibacterial, antifungal and anticancer activity, Bovine serum albumin luminescence quenching, pBluescsriptSK+ plasmid gel electrophoresis

http://dx.doi.org/10.1016/j.jinorgbio.2011.05.007

http://www.elsevier.com