ZB-2 Bioinorganic and Biomedical Chemistry

Head of the Group: Prof. Henryk Kozłowski

M.Sc. 1968, Ph.D. 1973, D.Sc. 1977, Prof. 1989

 

Ø   Vice-dean of the Faculty of Chemistry, Wrocław University (1995–1999).

Ø   Vice-head of Commission “Molecular Biology and Biotechnology” of the Wrocław division of the Polish Academy
of Sciences (1991–1998).

Ø   Member of Polish Chemical Society, Polish Biochemical Society, Polish Biophysical Society, Society of
Biological Inorganic Chemistry (SBIC), Fellow of the Royal Society of Chemistry, Society Polish Biophysical Society.

Ø   Member of editorial boards of Inorganica Chimica Acta (1982–1989), Metal Based Drugs (1992–1996),
JCS Dalton Transactions (1997–2003), Bioinorganic Chemistry and Applications (since 12.08.2002), New Journal
of Chemistry (since 2003) and Polish Journal of Chemistry (since 2003).

Ø   Chairman of the Management Committee of COST Action D8 “Chemistry of Metals in Medicine” (2000–2001).

Ø   Polish delegate to the Management Committee for COST D20 “Metal Compounds in the Treatment of Cancer
and Virial Diseases MCCV” (since 21.06.2001) and COST D34 “Molecular Targeting and Drug Design
in Neurological and Bacterial Diseases” (since 2005).

 

Research staff:

Ø   Prof. Jeżowska-Bojczuk Małgorzata

Ø   Prof. Kowalik-Jankowska Teresa

Ø   Dr. Urbańska Jadwiga, D. Sc.

Ø   Dr. Cukierda Tadeusz

Ø   Dr. Giera Edward

Ø   Dr. Gumienna-Kontecka Elżbieta

Ø   Dr. Łuczkowski Marek

Ø   Dr. Podsiadły Halina

Ø   Dr. Starosta Radosław

Ø   Krzywoszyńska Karolina, M.Sc.

Ø   Kucharczyk-Klamińska Marzena, M. Sc.

Ø   Maciąg Anna, M. Sc.

Ø   Nagaj Justyna, M. Sc.

Ø   Pietruszka Marta, M. Sc.

Ø   Potocki Sławomir, M. Sc.

Ø   Pyrkosz Monika, M. Sc.

Ø   Rowińska-Żyrek Magdalena, M. Sc.

Ø   Stokowa Kamila, M. Sc.

Ø   Szebesczyk Agnieszka, M. Sc.

Ø   Witkowska Danuta, M. Sc.

Ø   Zbyryt Aleksandra, M. Sc.

 

 

Research topics:

 

Ø   Structure and thermodynamics of bioinorganic systems.

Ø   Metal interactions with natural peptides and their derivatives; pesticides; nucleotides and nucleic acids.

Ø   Interactions of metal ions with peptides and drugs; modification of hormone bioactivity by various metal ions;
structure and activity of metalloenzymes; molecular toxicology and mechanisms of metal-related carcinogenesis.

Ø   Interactions of metal ions with aminosugars, sugar acids and aminoglycosidic antibiotics as potential mechanisms
of increasing their bioactivity.

Ø   Chelating agents for toxic metals and effect of toxic metal on biomolecules.

Ø   Coordination ability of phosphorus analogs of amino acids and peptides.

Ø   Enzyme inhibition.

Ø   Impact of metal ions on biochemistry and chemistry of drugs.

Ø   Interaction and transport of drugs by serum proteins.

Ø   Mechanisms of electroreduction of metal complexes at mercury electrode.

Ø   Thermochemistry of coordination compounds.

Ø   Mechanism of neurodegeneration.

 

 

Special equipment:

 

Ø   UV-Visible spectrophotometers (Beckman, Cary 50, Cary 300)

Ø   Fluorescence spectrophotometer (Cary Eclipse)

Ø   Gel Electrophoresis

Ø   Equipment for liophilisation and mineralisation

Ø   HPLC, HP

Ø   The potentiometric automatic titrators: Molspin

 

 

Recent research achievements:

 

Ø   Proposal for the model of interactions of Cu2+ ions with the proteins essential in the neurodegenerative processes.

Ø   Evaluation of the oxidative and coordination properties of cupric complexes of aminoglycoside antibiotics.

Ø   The Influence of copper ions on the structure and conversion PrPc (left picture) to PrPSc (right picture). Physiologically
copper ions are transported across cellular membrane into cytoplasm. The interaction of divalent metal ions (especially
copper ions) might play a key role in the conversion process what is the basis of neurodegeneration damage.

 

 

 

Selected papers:

 

1.     Y. S. Moroz, K. Kulon, M. Haukka, E. Gumienna-Kontecka, H. Kozłowski, F. Meyer,

      I. O. Fritsky

      Synthesis and Structure of [2×2] Molecular Grid Copper(II) and Nickel(II) Complexes with a New    

      Polidentate Oxime-Containing Schiff Base Ligand.

Inorg. Chem., 47, 5656-5665 (2008)

2.        M. Łuczkowski, M. Stachura, V. Schirf, B. Demeler, L. Hemmingsen and V. L. Pecoraro

        Design of Thiolate Rich Metal Binding Sites within a Peptidic Framework.  

        Inorg. Chem., 47, 10875–10888 (2008)   

3.        E. K. Gralka, D. Valensin, K. Gajda, D. Bacco, Ł. Szyrwiel, M. Remelli,

   G. Valensin, W. Kamasz, W. Barańska-Rybak, H. Kozłowski
   Copper(II) coordination outside the tandem repeat region of an unstructured domain of  

    chicken prion protein.
    Mol. BioSyst., 5, 497-510, (2009)

4.        Kozłowski H., Janicka-Kłos A., Brasuń J, Gaggelli E., Valensin D., Valensin G.
Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution
 and regulation).
Coord. Chem. Rev., 253, 2665-2685, (2009)

5.        Rowińska-Żyrek M., Valensin D., Szyrwiel Ł., Grzonka Z., Kozłowski H.
Specific interactions of Bi(III) with the Cys-Xaa-Cys unit of a peptide sequence.
Dalton Trans., 9131-9140, (2009)

6.        Valensin G., Molteni E., Valensin D., Taraszkiewicz M. P., Kozłowski H.
Molecular dynamics study of the Cu2+ binding-induced "structuring" of the N-terminal domain of human prion protein.
J. Phys. Chem. B., 113, 3277-3279, (2009)

7.        L.V. Penkova, A. Maciąg, E.V. Rybak-Akimova, M. Haukka, V.A. Pavlenko,

      T.S. Iskenderov, H. Kozlowski, F. Mayer, I.O. Fristky

       Efficient catalytic phosphate ester cleavage by binuclear Zinc(II) pyrazolate complexes as   

       functional models of metallophosphatases.

       Inorg.Chem., 48, 6960-6971, (2009)

8.        D. Balenci, G. Bonechi, N. D'Amelio, E. Gaggelli, N. Gaggelli, E. Molteni,

       G. Valensin, W. Szczepanik, M. P. Dziuba, G. Święcicki, M. Jeżowska-Bojczuk
       Structural features and oxidative stress towards plasmid DNA of apramycin copper  

       complex.
       Dalton Trans., 1123-1130, (2009)

9.        V.L. Pecoraro, A. F. A. Peacock, O. Iranzo, M. Łuczkowski Understanding the Biological Chemistry of Mercury Using
a de novo Protein Design Strategy.
ACS Symposium Series No. 1012/Bioinorganic Chemistry: Cellular Systems and Synthetic Models,
ed. E.C. Long, M.J. Boldwin, 2009, pp. 183-197.

10.     T. Kowalik-Jankowska, E. Jankowska, F. Kasprzykowski

        Coordination abilities of fragment containing D1 and H12 residues of neuropeptide gamma and    

        products of metal-catalyzed oxidation.

        Inorg. Chem., 49, 2182 – 2192 (2010)